American Bouvier des Flandres Club
  • Home
  • About Us
    • Code of Ethics
    • Committees
    • Constitution & By-Laws
    • Contact Us
    • Membership Info
    • Officers & Board of Directors
    • Club Officer History
    • Partner Organizations
    • President's Message
  • Bouvier Info
    • Get to Know the Bouvier
    • AKC Breed Standard
    • Articles of Interest >
      • A Farmer's Dog
      • Function and Purpose of the Bouvier
      • Diet Associated Dilated Cardiomyopathy
      • Canine Hemangiosarcoma Cells
      • Getting the Edge – The Owner/Handler
      • Makin' It Look Easy - The All-Breed Handler
      • Taking it to the Next Level - The Making of a Special's Dog
      • Losing is Only Fun if You're Dieting
      • Why I Love Herding
    • Find a Bouvier
    • Beginners Guide to the Bouvier >
      • Beginner's Guide to the Bouvier
      • How to Read a Pedigree
      • How to Select a Breeder
      • Selecting Your Bouvier Puppy
      • What About a Rescue Dog?
    • Judges Education
    • Breeder Judges & Mentors
    • Position on cross-breeding bouviers
  • Events & News
    • National Specialty
    • Upcoming Events & News
    • Past National Specialties >
      • 2018 Specialty Results
  • Programs
    • Futurity
    • Multi-Level Performance
    • Outstanding Sportsmanship
    • Owner/Handler and Owner/ Breeder/ Handler
    • Register of Merit (ROM) >
      • ROM: Program Info
      • ROM: Sires and Dams by Rank
      • ROM: Sires and Dams in Alphabetical Order
    • Top 20 Bouviers >
      • Top 20: Annual Celebration
      • Top 20: Breeder Honor Roll
      • Top 20: Conformation Program
      • Top 20: Conformation Winners
      • Top 20: Performance Program
    • Versatile Bouvier >
      • Versatile Bouvier Program Information
      • Versatile Bouvier Award Recipients 2015-2024
      • Versatile Bouvier Award Recipients 2005-2014
      • Versatile Bouvier Award Recipients 1995-2004
    • Volunteer of the Year
  • Statistics
    • Current Statistics >
      • 2023 >
        • Top 20 NOHS 2022-2023
        • Top 20 Statistics: Conformation 2022-2023
        • Best in Show/Group 2022
        • Best of Breed 2022
        • Top Producers 2022
        • Junior Handler - 2022
    • Performance Statistics Archive >
      • 2022 >
        • Agility 2022
        • Herding 2022
        • Obedience 2022
        • Other Titles Earned 2022
        • Rally 2022
      • 2021 >
        • Agility 2021
        • Herding 2021
        • Obedience 2021
        • Other Titles Earned 2021
        • Rally 2021
        • Top Producers 2021
      • 2020 >
        • Agility 2020
        • Herding 2020
        • Obedience 2020
        • Other Titles Earned 2020
        • Rally 2020
        • Top Producers 2020
      • 2019 >
        • Best in Show/Group 2019
        • Best of Breed 2019
        • Agility 2019
        • Herding 2019
        • Other Titles Earned 2019
        • Rally 2019
        • Top Producers 2019
      • 2018 >
        • Best in Show/Group 2018
        • Best of Breed 2018
        • Agility 2018
        • Herding 2018
        • Obedience 2018
        • Other Titles Earned 2018
        • Rally 2018
        • Top Producers 2018
    • Conformation Statistics Archive >
      • 2021-2022 >
        • Top 20: NOHS 2021-2022
        • Top 20 Statistics: Conformation 2021-2022
      • 2020-2021 >
        • Top 20: Conformation - 2020-2021
        • Top 20: NOHS -- 2020-2021
        • Top 20: Performance - 2020-2021
      • 2019-2020 >
        • Top 20 Statistics: Conformation - 2019-2020
        • Natl. Owner-Handled Series 2019-20
        • Top 20 Statistics: Performance - 2019-2020
      • 2018-2019 >
        • Top 20 Statistics: Conformation - 2018-2019
        • Top 20 Statistics: NOHS - 2018-2019
        • Top 20 Statistics: Performance - 2018-2019
  • A Versatile Breed
    • Work & Play
    • Carting
  • Member Area
    • Member Payments & Donations
    • Member Portal
    • Breed Mentors
Picture
Information on an interesting AKC Canine Health Foundation grant that Bouvier Health Foundation helped fund last year.

Research Progress Report Summary

Grant 02864-A: Luteinizing Hormone Receptor Activation in Canine Hemangiosarcoma Cells
Principal Investigator: Michelle Kutzler, DVM, PhD
Research Institution: Oregon State University
Grant Amount:
$11,718

Start Date: 2/1/2021 End Date: 1/31/2022
Progress Report: Mid-Year 1
Report Due: 7/31/2021 Report Received: 7/29/2021

(The content of this report is not confidential and may be used in communications with your organization.)

Original Project Description:
Hemangiosarcoma is an aggressive, silent cancer that sometimes snares its victims without any sign of

illness. In the U.S., hemangiosarcoma is believed to be responsible for the deaths of tens of thousands
of dogs each year. German Shepherd Dogs, Golden Retrievers, and Labrador Retrievers are most
commonly affected but this cancer affects all dogs. While there is no cure, early surgical intervention
and chemotherapy treatment may prolong the lives of dogs afflicted with hemangiosarcoma.
Additional treatment options are needed to increase life expectancy and possibly even prevent the
development of this deadly disease. Several studies have shown that spayed female dogs have a two-
to ten-fold increase for developing hemangiosarcoma compared to intact female dogs. This may be
due to overproduction of luteinizing hormone (LH) following spay or neuter. Investigators have
previously demonstrated that hemangiosarcoma tissues collected from dogs have binding sites for LH.
The proposed research will determine if LH binding to these sites increases cancer cell growth. The
results of this research may allow for a better understanding of the relationship between spaying or
neutering and the development of hemangiosarcoma. In addition, future development of a method to
reduce LH secretion in spayed or neutered dogs may lower the risk for some breeds to develop
hemangiosarcoma.

Publications: There are no publications from this research yet.

Presentations:

The results from the LHR immunocytochemistry will be presented as a virtual poster at the 2021
Oregon State University Celebrating Undergraduate Excellence conference in September 2021. There
are no other presentations from this research yet.

Report to Grant Sponsor from Investigator:
In the United States, spaying and neutering of dogs and cats is commonly performed to prevent the
birth of unwanted pets. However, surgically removing the ovaries or testes may have unexpected
consequences. Dogs that have been spayed or neutered have an increased risk for developing obesity,
urinary incontinence, hypothyroidism, hyperadrenocorticism, diabetes, cruciate ligament tears, hip
dysplasia, and cancer. Hemangiosarcoma is a rapidly growing, highly invasive cancer arising from the
lining of blood vessels of any tissue. More than half of all canine hemangiosarcoma tumors are in the
spleen. Spayed female dogs are reported to have two to ten times the risk for developing splenic
hemangiosarcoma compared to intact female dogs. This funded study is investigating the hormonal
and cellular relationships between spaying/neutering and the development of splenic
hemangiosarcoma so that new treatments may be available in the future to extend life expectancies of
dogs with cancer.
Questions or feedback? Contact a Committee or the Officers & Board of Directors directly.
All photos, illustrations, charts, articles or content may not be reproduced without the express permission of the ABdFC and the photographer.

Site Map  | Copyright ©2021 The American Bouvier des Flandres Club (ABdFC).

Get Social with Us
Like us on Facebook
  • Home
  • About Us
    • Code of Ethics
    • Committees
    • Constitution & By-Laws
    • Contact Us
    • Membership Info
    • Officers & Board of Directors
    • Club Officer History
    • Partner Organizations
    • President's Message
  • Bouvier Info
    • Get to Know the Bouvier
    • AKC Breed Standard
    • Articles of Interest >
      • A Farmer's Dog
      • Function and Purpose of the Bouvier
      • Diet Associated Dilated Cardiomyopathy
      • Canine Hemangiosarcoma Cells
      • Getting the Edge – The Owner/Handler
      • Makin' It Look Easy - The All-Breed Handler
      • Taking it to the Next Level - The Making of a Special's Dog
      • Losing is Only Fun if You're Dieting
      • Why I Love Herding
    • Find a Bouvier
    • Beginners Guide to the Bouvier >
      • Beginner's Guide to the Bouvier
      • How to Read a Pedigree
      • How to Select a Breeder
      • Selecting Your Bouvier Puppy
      • What About a Rescue Dog?
    • Judges Education
    • Breeder Judges & Mentors
    • Position on cross-breeding bouviers
  • Events & News
    • National Specialty
    • Upcoming Events & News
    • Past National Specialties >
      • 2018 Specialty Results
  • Programs
    • Futurity
    • Multi-Level Performance
    • Outstanding Sportsmanship
    • Owner/Handler and Owner/ Breeder/ Handler
    • Register of Merit (ROM) >
      • ROM: Program Info
      • ROM: Sires and Dams by Rank
      • ROM: Sires and Dams in Alphabetical Order
    • Top 20 Bouviers >
      • Top 20: Annual Celebration
      • Top 20: Breeder Honor Roll
      • Top 20: Conformation Program
      • Top 20: Conformation Winners
      • Top 20: Performance Program
    • Versatile Bouvier >
      • Versatile Bouvier Program Information
      • Versatile Bouvier Award Recipients 2015-2024
      • Versatile Bouvier Award Recipients 2005-2014
      • Versatile Bouvier Award Recipients 1995-2004
    • Volunteer of the Year
  • Statistics
    • Current Statistics >
      • 2023 >
        • Top 20 NOHS 2022-2023
        • Top 20 Statistics: Conformation 2022-2023
        • Best in Show/Group 2022
        • Best of Breed 2022
        • Top Producers 2022
        • Junior Handler - 2022
    • Performance Statistics Archive >
      • 2022 >
        • Agility 2022
        • Herding 2022
        • Obedience 2022
        • Other Titles Earned 2022
        • Rally 2022
      • 2021 >
        • Agility 2021
        • Herding 2021
        • Obedience 2021
        • Other Titles Earned 2021
        • Rally 2021
        • Top Producers 2021
      • 2020 >
        • Agility 2020
        • Herding 2020
        • Obedience 2020
        • Other Titles Earned 2020
        • Rally 2020
        • Top Producers 2020
      • 2019 >
        • Best in Show/Group 2019
        • Best of Breed 2019
        • Agility 2019
        • Herding 2019
        • Other Titles Earned 2019
        • Rally 2019
        • Top Producers 2019
      • 2018 >
        • Best in Show/Group 2018
        • Best of Breed 2018
        • Agility 2018
        • Herding 2018
        • Obedience 2018
        • Other Titles Earned 2018
        • Rally 2018
        • Top Producers 2018
    • Conformation Statistics Archive >
      • 2021-2022 >
        • Top 20: NOHS 2021-2022
        • Top 20 Statistics: Conformation 2021-2022
      • 2020-2021 >
        • Top 20: Conformation - 2020-2021
        • Top 20: NOHS -- 2020-2021
        • Top 20: Performance - 2020-2021
      • 2019-2020 >
        • Top 20 Statistics: Conformation - 2019-2020
        • Natl. Owner-Handled Series 2019-20
        • Top 20 Statistics: Performance - 2019-2020
      • 2018-2019 >
        • Top 20 Statistics: Conformation - 2018-2019
        • Top 20 Statistics: NOHS - 2018-2019
        • Top 20 Statistics: Performance - 2018-2019
  • A Versatile Breed
    • Work & Play
    • Carting
  • Member Area
    • Member Payments & Donations
    • Member Portal
    • Breed Mentors